Last year there was a major discovery of circuitry for how our immune system in the body activates the brain. In the past couple of weeks we’re seeing progress in understanding how the brain controls the immune system, including the clinical relevance, the first of its kind, a new FDA approval. In this issue of Ground Truths I’ll review the recent reports that spotlight the pivotal role of reciprocal interactions between our brain and immune system.

1. Just seeing a person with signs of infection activates our immune response!

2. An implantable neuroimmune modulation device for autoimmune disease

3. The Alzheimer’s Disease Risk of APOE4 Carriers is Mediated via the Immune System

4. A Multiomics Study for Alzheimer’s and Cerebrovascular Diseases